The body’s internal system that turns one thyroid hormone into another isn’t enough on its own to explain the timing and levels of these hormones throughout the day.

Evidence from Studies

Supporting (1)

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PBK Modeling of Thyroid Hormone Circadian Rhythm: Elucidating Thyroidal and Extrathyroidal Contributions to Thyroid Hormone Chronobiology

Computational/Algorithm Study

The study found that the thyroid gland alone can't explain the timing and levels of the hormone T3 in the blood over the day — other tissues in the body also play a key role.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

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Source Study

PBK Modeling of Thyroid Hormone Circadian Rhythm: Elucidating Thyroidal and Extrathyroidal Contributions to Thyroid Hormone Chronobiology

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DOI: 10.1152/physiol.2025.40.s1.1969

Similar Assertions

There's a computer model that can mimic how our thyroid hormones rise and fall during the day, and it works by timing how the body converts one hormone into another in different places, with the body's tissues getting a 3-hour head start over the thyroid gland.

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87%

Your body's daily rhythm of thyroid hormones isn't caused by just one thing—like the thyroid working on a schedule or how the hormone moves through your blood. It's more complicated than that.

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81%