The Claim
The phosphorylation of p70S6K at Thr389 one hour after resistance exercise is not correlated with long-term muscle hypertrophy in young men.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In young men, the level of a specific molecular signal detected one hour after weight training does not predict how much muscle mass will be gained over time.
See the scientific wording
The phosphorylation of p70S6K at Thr389 one hour after resistance exercise is not correlated with long-term muscle hypertrophy in young men, suggesting that early post-exercise signaling responses are not reliable predictors of muscle growth.
When you lift weights, the tension on your muscles triggers multiple pathways that increase the production of muscle proteins over time. Even if one specific signal (p70S6K) doesn't rise right after exercise, other signals can activate the same process later or through different routes. What matters most is that the muscle is challenged enough to keep making more protein with each workout, and over weeks, that adds up to bigger muscles — no matter which signal showed up first.
What the research says
1 studyStudy: Resistance exercise load does not determine training-mediated hypertrophic gains in young men.
Just because a muscle signal goes up right after lifting weights doesn’t mean you’ll grow more muscle over time—this study found no link between that early signal and actual muscle growth after 10 weeks of training.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.