The Claim

In adults with nonalcoholic fatty liver disease who are treated with GLS at a dose of 8.12 g/day for 12 weeks, the degree of reduction in gamma-glutamyl transferase (GGT) and waist circumference is positively correlated with the reduction in serum fibroblast growth factor 21 (FGF-21), with correlation coefficients of r = 0.374 and r = 0.343 respectively, indicating that changes in FGF-21 levels may reflect improvements in liver and metabolic health.

Source: An Open-Label Exploratory Clinical Trial Evaluating the Effects of GLS (Coptidis Rhizoma-Evodiae Fructus 2 : 1) on Fibroblast Growth Factor 21 in Patients with Nonalcoholic Fatty Liver Disease

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
63score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Correlation
1 study reviewed
In plain English

If you have fatty liver and take a supplement called GLS for 12 weeks, the more your FGF-21 levels go down, the more your liver enzyme and belly size tend to improve — suggesting this protein might be a marker for better liver and metabolic health.

See the scientific wording

In adults with nonalcoholic fatty liver disease treated with GLS (8.12 g/day) for 12 weeks, the magnitude of reduction in gamma-glutamyl transferase (GGT) and waist circumference is positively correlated with the reduction in serum fibroblast growth factor 21 (FGF-21), with correlation coefficients of r = 0.374 and r = 0.343 respectively, suggesting that FGF-21 changes may reflect improvements in liver and metabolic health.

What the research says

1 study
  1. Study: An Open-Label Exploratory Clinical Trial Evaluating the Effects of GLS (Coptidis Rhizoma-Evodiae Fructus 2 : 1) on Fibroblast Growth Factor 21 in Patients with Nonalcoholic Fatty Liver Disease

    The study tested the same supplement and found that as liver enzyme levels and waist size improved, so did a blood marker linked to liver health, just like the claim says.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.