If you have fatty liver and take a supplement called GLS for 12 weeks, the more your FGF-21 levels go down, the more your liver enzyme and belly size tend to improve — suggesting this protein might be a marker for better liver and metabolic health.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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An Open-Label Exploratory Clinical Trial Evaluating the Effects of GLS (Coptidis Rhizoma-Evodiae Fructus 2 : 1) on Fibroblast Growth Factor 21 in Patients with Nonalcoholic Fatty Liver Disease

Randomized Controlled Trial

Human

2022

The study tested the same supplement and found that as liver enzyme levels and waist size improved, so did a blood marker linked to liver health, just like the claim says.

Contradicting (0)

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

An Open-Label Exploratory Clinical Trial Evaluating the Effects of GLS (Coptidis Rhizoma-Evodiae Fructus 2 : 1) on Fibroblast Growth Factor 21 in Patients with Nonalcoholic Fatty Liver Disease

Score: 63

DOI: 10.1155/2022/4583645

Similar Assertions

For people with fatty liver disease, taking a supplement called GLS for 12 weeks along with healthy lifestyle changes seems to lower a stress-related liver hormone (FGF-21) more than another supplement. This might mean their liver isn’t working as hard to stay healthy after treatment.

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