quantitative
Analysis v1
Strong Support
People born with certain gene changes that lower their bad cholesterol over their whole life have a lower chance of heart disease — the more their cholesterol is lowered, the lower their risk.
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Evidence from Studies
Supporting (1)
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Community contributions welcome
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Sequence variations in PCSK9, low LDL, and protection against coronary heart disease.
Cohort Study
Human
2006 Mar 23The study looked at people born with genetic changes in the PCSK9 gene that lower their bad cholesterol their whole life, and found the more their cholesterol was lowered, the lower their risk of heart disease — just like the claim says.
Contradicting (0)
0
Community contributions welcome
No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.