People without diabetes who are overweight or obese and take a weekly 2.4 mg dose of semaglutide often get mild stomach issues like nausea, diarrhea, or vomiting, but most keep taking it — only a small number stop because of these side effects.

When people take semaglutide 2.4 mg, many feel sick to their stomach, throw up, or have constipation or diarrhea—but very few stop taking it because of these side effects.

For people with heart disease, taking semaglutide means about 1 in 12 will stop treatment because of stomach problems like nausea or diarrhea — much more common than with a dummy pill.

Taking a weekly semaglutide shot (2.4 mg) for about a year helps people with extra weight feel more physically capable and improves their overall quality of life—more than a dummy pill would.

Taking a weekly semaglutide shot (2.4 mg) for about a year and a half can help lower blood pressure, blood sugar, bad cholesterol, and body-wide inflammation in adults with extra weight but no diabetes—better than a placebo.

For adults with heart disease and obesity who don’t have diabetes, taking a weekly semaglutide shot (2.4 mg) leads to more than twice as many people stopping treatment because of side effects compared to those taking a dummy shot.