Even if someone eats a lot of food with 6-Phytase, the amount they’d get is thousands of times lower than the highest dose that didn’t harm rats — so it’s likely very safe.

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Evidence from Studies

Supporting (1)

12

Community contributions welcome

12

Safety evaluation of the food enzyme 6‐Phytase from the genetically modified Trichoderma reesei strain AR‐766

Cross-Sectional Study

Animal

2025 Feb

The study looked at how safe a food enzyme called 6-Phytase is and found that the amount people would eat is tiny compared to the safe amount seen in animal tests, so the safety margin is very large.

Contradicting (0)

0

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Safety evaluation of the food enzyme 6‐Phytase from the genetically modified Trichoderma reesei strain AR‐766

Score: 12

DOI: 10.2903/j.efsa.2025.9226

Similar Assertions

A rat study found that even the highest dose of 6-Phytase tested didn’t cause any real harm, even though there were tiny changes in blood tests that scientists didn’t think mattered.

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81%

Toddlers in Europe might be exposed to up to a tiny amount — 0.071 milligrams per kilogram of body weight — of an enzyme called 6-Phytase each day from foods like bread, cereals, and plant-based milks, especially if it's added at the highest allowed levels. Older kids and adults likely get much less.

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77%