This claim is about a compound called 8-prenylnaringenin (found in hops) and how it affects the uterus and uterine lining in rats that had their ovaries removed. The claim says it has very small growth effects on these tissues, and importantly, these effects don't change no matter how much of the compound is given.

6

Pro

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Against

Evidence from Studies

Supporting (1)

6

Community contributions welcome

6

Tissue specificity of 8-prenylnaringenin: protection from ovariectomy induced bone loss with minimal trophic effects on the uterus.

Cohort Study

Animal

2005 Nov

The study gave 8-PN to rats without ovaries and found it protects bones while having very small effects on the uterus and endometrium that don't change with different doses - exactly what the claim says.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Tissue specificity of 8-prenylnaringenin: protection from ovariectomy induced bone loss with minimal trophic effects on the uterus.

Score: 6

DOI: 10.1016/J.JSBMB.2005.05.009

Similar Assertions

A compound found in hops called 8-prenylnaringenin (8-PN) appears to be much weaker at stimulating the uterus and uterine lining than the hormone estrogen, even when both are given at doses that protect bones equally well.

6

0

80%

A compound called 8-prenylnaringenin (8-PN) was found to fully stop bone loss in rats that had their ovaries removed - these rats are used to study a condition similar to osteoporosis that happens to women after menopause.

6

0

76%

Scientists found that giving a plant compound called 8-prenylnaringenin to female rats without ovaries, at a specific dose for three days, made more little bud-like structures grow in their mammary glands than two other similar compounds did.

8

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73%

Scientists tested a plant compound called 8-prenylnaringenin in special mice that have been genetically modified to show when estrogen-related activity is happening, and they found that this compound strongly activated estrogen-like effects in the mice's prostate glands.

6

0

71%