When the seals between gut cells break down, stuff from the gut can leak out and set off body-wide immune alarms.

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Evidence from Studies

Supporting (1)

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Increased Intestinal Permeability: An Avenue for the Development of Autoimmune Disease?

Narrative Review

Animal

The study explains that when the 'seals' between gut cells break down, harmful substances can leak out and cause immune problems elsewhere in the body, which matches the claim.

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Increased Intestinal Permeability: An Avenue for the Development of Autoimmune Disease?

Score: 1

DOI: 10.1007/s12403-023-00578-5

Similar Assertions

A bacterial enzyme used in food processing might glue together the cells lining your gut, making it leakier — and for people with celiac disease, this could make their symptoms worse.

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In people with celiac disease, a bacterial enzyme called microbial transglutaminase might glue together the tiny seals between gut cells, making the gut leakier and letting more of the harmful wheat protein (gliadin) slip through, which could make symptoms worse.

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