The Claim
In rats, a second bout of resistance exercise performed 48 hours after the first bout is associated with no significant increase in mTORC1 signaling, as measured by p-S6K1 and p-S6 phosphorylation, unlike the 26-fold and 5-fold increases observed after the initial bout, indicating rapid dampening of anabolic signaling with repeated stimuli.
What the research says
Roughly balanced
Support and challenge are close. The picture may shift as more studies come in.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
When rats do the same hard workout again two days later, their muscles don't get the same boost in growth signals as the first time, showing that the body quickly gets used to repeated exercise.
See the scientific wording
A second bout of resistance exercise in rats 48 hours after the first bout is associated with no significant increase in mTORC1 signaling (p-S6K1 and p-S6 phosphorylation), unlike the 26-fold and 5-fold increases seen after the initial bout, demonstrating rapid dampening of anabolic signaling with repeated stimuli.
What the research says
1 studyThe study shows that the second workout made the muscle growth signals much weaker than the first workout, which is even more dramatic than just 'no increase' as claimed.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.