The senolytic drug fisetin, despite being given to old mice for several months, did not reduce the markers of aging cells in their organs

Evidence from Studies

No evidence studies found yet.

What Would Prove This

Per GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this claim, ordered from strongest to weakest.

1

Randomized Controlled Trials

Whether fisetin reduces senescent cells in humans

RCT of fisetin in older adults with biopsy-proven senescent cell burden measurements before and after treatment

2

Case-Control Studies

Senolytic effects in human tissues

Case-control comparing senescent cell markers in fisetin users vs non-users

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Source Study

Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used

Score: 13

DOI: 10.1007/s11357-023-01011-0

The senolytic drug fisetin, despite being given to old mice for several months, did not reduce the markers of aging cells in their organs

Claim Context

Evidence from Studies

What Would Prove This

Source Study

Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used