Scientists tested a plant compound called 8-prenylnaringenin in special mice that have been genetically modified to show when estrogen-related activity is happening, and they found that this compound strongly activated estrogen-like effects in the mice's prostate glands.

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Pro

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Against

Evidence from Studies

Supporting (1)

6

Community contributions welcome

6

Tissue specificity of 8-prenylnaringenin: protection from ovariectomy induced bone loss with minimal trophic effects on the uterus.

Cohort Study

Animal

2005 Nov

The study gave 8-PN to transgenic mice and found that it caused strong estrogenic activity in the prostate, exactly matching what the claim says.

Contradicting (0)

0

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Tissue specificity of 8-prenylnaringenin: protection from ovariectomy induced bone loss with minimal trophic effects on the uterus.

Score: 6

DOI: 10.1016/J.JSBMB.2005.05.009

Similar Assertions

This claim is about a compound called 8-prenylnaringenin (found in hops) and how it affects the uterus and uterine lining in rats that had their ovaries removed. The claim says it has very small growth effects on these tissues, and importantly, these effects don't change no matter how much of the compound is given.

6

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