The study found that what kind of fat is inside the bad cholesterol matters more for heart disease than how big or small the particles are.

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Evidence from Studies

Supporting (1)

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Dietary polyunsaturated fat modifies low-density lipoproteins and reduces atherosclerosis of nonhuman primates with high and low diet responsiveness.

Cohort Study

Animal

1995 Aug

The study found that when LDL particles in monkeys had more of a specific fat called cholesteryl oleate, they were more likely to get artery clogs—even if the particles were big or small. So, what’s inside the LDL matters more than how big the LDL is.

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No contradicting evidence found

Source Study

Dietary polyunsaturated fat modifies low-density lipoproteins and reduces atherosclerosis of nonhuman primates with high and low diet responsiveness.

Score: 10

DOI: 10.1093/AJCN/62.2.463S

Similar Assertions

When monkeys ate a high-fat diet, their bad cholesterol went up not because each particle got fuller of cholesterol, but because there were way more particles floating around in their blood.

73%

When monkeys ate more linoleic acid (a healthy fat), the fat inside their bad cholesterol particles changed — less of one type and more of another, which might be less harmful.

72%