Strong Support
mechanistic
Analysis v1
History

After heart surgery, a drug called tranexamic acid can build up in the fluid around the brain and spinal cord, and this buildup might interfere with brain signals in a way that increases the chance of seizures after surgery.

39
Pro
0
Against

Evidence from Studies

Supporting (1)

39

Community contributions welcome

39

Tranexamic acid concentrations associated with human seizures inhibit glycine receptors.

Randomized Controlled Trial
Human & Animal & In Vitro
2012 Dec

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

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