The Claim

17-α-estradiol treatment administered to male mice beginning at 16 months of age was associated with a 7% increase in 90th percentile maximum lifespan (p=0.004, Wang-Allison test), indicating extension of both median and maximum lifespan.

Source: 17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
13score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Correlation
1 study reviewed
In plain English

Giving male mice a special compound called 17-α-estradiol when they were middle-aged (16 months) helped them live about 7% longer, specifically extending their maximum lifespan.

See the scientific wording

17-α-estradiol treatment was associated with a 7% increase in 90th percentile lifespan (maximum lifespan) in male mice when started at 16 months (p=0.004, Wang-Allison test), indicating extension of both median and maximum lifespan

What the research says

1 study

  1. Study: 17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

    The study tested the exact same drug (17-α-estradiol) in the exact same way (starting at 16 months in male mice) and found exactly what the claim describes: a 7% increase in maximum lifespan with a p-value of 0.004.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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