The Claim

Pseudouridine-modified mRNA vaccination can induce +1 ribosomal frameshifting during translation, resulting in the synthesis of unintended peptide antigens that trigger off-target T cell responses in both mice and humans, which may contribute to autoimmune or inflammatory complications.

Source: Long‐lasting, biochemically modified mRNA, and its frameshifted recombinant spike proteins in human tissues and circulation after COVID‐19 vaccination

What the research says

Roughly balanced

Support and challenge are close. The picture may shift as more studies come in.

Supports
1score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
1 study reviewed
In plain English

Getting an mRNA vaccine with a special chemical tweak might accidentally make your cells produce weird proteins that could confuse your immune system and possibly lead to autoimmune problems — in both people and mice.

See the scientific wording

Vaccination with pseudouridine-modified mRNA may induce +1 ribosomal frameshifting during translation, leading to the production of unintended peptide antigens that elicit off-target T cell responses in both mice and humans, potentially contributing to autoimmune or inflammatory complications.

What the research says

1 study
  1. Study: Long‐lasting, biochemically modified mRNA, and its frameshifted recombinant spike proteins in human tissues and circulation after COVID‐19 vaccination

    The study shows that the COVID-19 mRNA vaccines can cause cells to make unexpected proteins due to a glitch in reading the genetic code, and these abnormal proteins can trigger immune responses that might mistakenly attack the body’s own tissues.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.