Medicines that target the GLP-1 brain system can reduce cravings for drugs without making enjoyable things feel less fun, at least in animal studies.

Diabetes drugs called GLP-1 agonists might help people overcome addictions by reducing how pleasurable substances like alcohol, nicotine, and opioids feel in the brain.

Some parts of the brain that control pleasure and addiction have special spots (called GLP-1 receptors) that certain drugs can target, which might help reduce addictive behaviors by affecting brain chemicals like dopamine.

A type of diabetes drug might help reduce cravings and relapse in addiction by affecting brain signals tied to pleasure and reward — at least in animals.

Diabetes drugs like Ozempic might help with addiction by calming brain reward signals when someone is high, easing withdrawal symptoms like stress, and reducing cravings when they see triggers.

Medications that activate GLP-1 receptors are associated with lower urges to eat high-calorie foods and reduced persistent thoughts about food in people.