This injection makes the waist smaller without changing fat on the arms, legs, or just under the skin.
Scientific Claim
Tesamorelin (2 mg subcutaneous daily for 6 months) reduces waist circumference by 2% in HIV-infected adults on antiretroviral therapy with abdominal fat accumulation, compared to placebo, without altering subcutaneous abdominal or limb fat.
Original Statement
“Trunk fat (P < 0.001), waist circumference (P = 0.02), and waist-hip-ratio (P = 0.001) improved, with no change in limb or abdominal SC fat.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
The RCT design and statistical significance (P = 0.02) support definitive causal language for this secondary outcome.
Evidence from Studies
Supporting (1)
This study found that a daily shot of tesamorelin helped HIV patients lose belly fat without losing fat in their arms or legs, and their waist got smaller — just like the claim says.