quantitative
Analysis v1
Strong Support
Scientists found that one specific genetic change called A554V makes a protein stick to DNA much stronger than other similar genetic changes do - about 8 times stronger compared to only 2.5-3.5 times stronger for the others.
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Evidence from Studies
Supporting (1)
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Community contributions welcome
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Disease-Associated Mutation A554V Disrupts Normal Autoinhibition of DNMT1
Cross-Sectional Study
In Vitro
2023 SepThe study confirms that the A554V mutation increases DNA binding affinity by about 8-fold, matching the claim. However, it doesn't actually test how this compares to other mutations, so the claim's statement that A554V is worse than other mutations isn't directly verified.
Contradicting (0)
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Community contributions welcome
No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.