Scientists discovered that blocking a specific cell signaling pathway called mTOR can help mammals live longer. This finding shows that the TOR pathway is involved in controlling how long mammals live.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Randomized Controlled Trial

Animal

2009 Jul 16

The study gave mice a drug called rapamycin that blocks mTOR signaling, and this made the mice live longer. This was the first time anyone showed that blocking mTOR can extend lifespan in a mammal, which proves the claim is true.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Score: 18

DOI: 10.1038/nature08221

Similar Assertions

Scientists found that a drug called rapamycin helps mice live longer, but it works better in female mice (14% longer) than in male mice (9% longer). This suggests the drug might affect males and females differently.

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