Three drugs that were thought might help mice live longer were tested, but none of them actually made the mice live longer at the doses given.

13

Pro

0

Against

Evidence from Studies

Supporting (1)

13

Community contributions welcome

13

17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

Cohort Study

Animal

2021 May

The study tested the exact same three drugs (candesartan cilexetil, geranylgeranylacetone, and MIF098) on the same type of mice (UM-HET3) and found that none of them significantly extended lifespan in either males or females - exactly matching what the claim says.

Contradicting (0)

0

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

Score: 13

DOI: 10.1111/acel.13328

Similar Assertions

Scientists tested three different compounds at specific doses in mice to see if they could help the mice live longer, but none of them made a meaningful difference in how long the mice lived.

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