The Claim
Triiodothyronine upregulates mRNA expression of multiple nuclear-encoded mitochondrial respiratory chain proteins, including subunits of complexes I, III, IV, and V, in human skeletal muscle.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Triiodothyronine increases the production of messenger RNA for proteins involved in the mitochondrial energy-producing complexes I, III, IV, and V in human skeletal muscle.
See the scientific wording
Triiodothyronine upregulates mRNA expression of multiple nuclear-encoded mitochondrial respiratory chain proteins, including subunits of complexes I, III, IV, and V, suggesting enhanced mitochondrial biogenesis or function in human skeletal muscle.
Triiodothyronine enters muscle cells and binds to receptors in the nucleus, which opens up tightly packed DNA, allowing the cell to read and copy instructions for making energy-producing machines inside mitochondria. This increases the production of proteins that form the electron transport chain, the machinery that generates cellular energy, and also boosts the tools needed to build those proteins inside mitochondria.
What the research says
1 studyStudy: In vivo regulation of human skeletal muscle gene expression by thyroid hormone.
This study gave people a thyroid hormone and found that their muscle cells turned on many genes related to making energy. This means the hormone helps the body build more of the tiny power plants inside muscle cells.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.