The Claim
Triiodothyronine increases mRNA expression of uncoupling protein 3 and adenine nucleotide translocases 1 and 2 in human skeletal muscle, leading to increased mitochondrial proton leak and uncoupled respiration.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Triiodothyronine raises the levels of specific messenger RNA molecules in human skeletal muscle that are involved in mitochondrial proton leak and uncoupled respiration.
See the scientific wording
Triiodothyronine increases mRNA expression of uncoupling protein 3 and adenine nucleotide translocases 1 and 2 in human skeletal muscle, suggesting a molecular basis for increased mitochondrial proton leak and uncoupled respiration.
Triiodothyronine enters muscle cells and turns on genes that make more uncoupling protein 3 and adenine nucleotide translocases, which create leaks in the mitochondria's inner membrane. These leaks let protons flow back into the mitochondria without making ATP, so energy is released as heat instead of being stored, increasing the body's energy use.
What the research says
1 studyStudy: In vivo regulation of human skeletal muscle gene expression by thyroid hormone.
This study showed that giving people a thyroid hormone made their muscle cells turn on more genes that help mitochondria burn energy as heat instead of storing it as fuel, which explains why metabolism speeds up.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.