In Graves’ disease, the immune system makes faulty antibodies that trick the thyroid into overproducing hormones, causing it to go into overdrive.
Evidence from Studies
Supporting (2)
Community contributions welcome
The study shows that antibodies from Graves’ disease patients can activate thyroid cells, which supports the idea that these antibodies cause the thyroid to overproduce hormones.
Activation of membrane-bound adenylcyclase by thyroid stimulating antibodies.
The study shows that antibodies from people with Graves’ disease turn on thyroid cells in a lab, just like the claim says they do.
Contradicting (1)
Community contributions welcome
In this mouse study, the antibodies blocked the thyroid instead of turning it on, which is the opposite of what happens in Graves’ disease.
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.