When predicting how much muscle a person will gain from training, accounting for how much they have trained in the past leads to more accurate predictions.
Mechanism
Synthesis from 1 study
People who’ve lifted weights a lot before don’t grow as much from the same workout as beginners, because their muscles get used to the stress. If you don’t know how much they’ve trained before, you’ll guess wrong about how much muscle they’ll gain.
Most probable mechanism
When someone has lifted weights a lot before, their muscles become less responsive to the same amount of stress, so they don’t grow as much from the same workout — if you don’t know how much they’ve trained before, you can’t tell why their muscles aren’t growing like someone new.
Chronic resistance training reduces the sensitivity of muscle satellite cells and mTOR signaling pathways to mechanical load and nutrient stimuli.
Reduced signaling sensitivity leads to diminished protein synthesis rates per unit of training stimulus compared to less-trained individuals.
Without accounting for prior training volume, predictions of hypertrophy assume uniform anabolic responsiveness, leading to overestimation in trained individuals and underestimation in novices.
Evidence from Studies
Supporting (1)
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