mechanistic
Analysis v1
Strong Support
When a certain gene is turned off in mice, it damages the stem cells that give hair its color—but not the regular color-making cells—so the hair gradually loses pigment and turns gray or white.
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Evidence from Studies
Supporting (1)
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Community contributions welcome
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Mitochondrial deoxyguanosine kinase depletion induced ROS causes melanocyte stem cell exhaustion and hair greying
Cohort Study
Animal
2025 Jun 16The study shows that turning off a gene called DGUOK in mice causes their hair to grey because it damages the stem cells that make hair color, but not the color-making cells themselves. This happens because of a buildup of harmful molecules and cell death in the stem cells.
Contradicting (0)
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Community contributions welcome
No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.