mechanistic
Analysis v1
Strong Support
Turning off certain genes in mice changes their body chemistry in ways that depend on the tissue and whether they're male or female — and these changes are linked to how they age.
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Evidence from Studies
Supporting (1)
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Community contributions welcome
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The study looked at mice that were genetically changed to remove certain genes (IDO1 and IDO2), and found that this change caused differences in molecules linked to aging, depending on the tissue and the sex of the mouse—just like the claim says.
Contradicting (0)
0
Community contributions welcome
No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.