Turning on a specific cell receptor called TGR5 with a special compound makes mouse muscle cells grow bigger by switching on growth-related genes and signals — which might one day help treat muscle...

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Evidence from Studies

Supporting (1)

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Association of lithocholic acid with skeletal muscle hypertrophy through TGR5-IGF-1 and skeletal muscle mass in cultured mouse myotubes, chronic liver disease rats and humans

Cross-Sectional Study

Human & Animal & In Vitro

2022 Oct 7

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No contradicting evidence found

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Source Study

Association of lithocholic acid with skeletal muscle hypertrophy through TGR5-IGF-1 and skeletal muscle mass in cultured mouse myotubes, chronic liver disease rats and humans

Score: 51

DOI: 10.7554/eLife.80638

Similar Assertions

In lab-grown mouse muscle cells, a substance called lithocholic acid makes the muscle cells grow bigger, especially at a specific dose, and this happens through a particular chain reaction in the cells.

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