When scientists turn on a specific brain circuit in mice that connects fear and stress areas to the metabolism control center, the liver starts making more sugar from scratch—even though the stored sugar in the liver doesn’t change.

13

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Against

Evidence from Studies

Supporting (1)

13

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13

Amygdala–liver signalling orchestrates glycaemic responses to stress

Cohort Study

Animal

2025 Oct

When mice are stressed, a brain circuit connected to the liver tells it to make more sugar from scratch—without touching stored sugar—and this is exactly what the claim says happens when you artificially turn on that same brain circuit.

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No contradicting evidence found

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Source Study

Amygdala–liver signalling orchestrates glycaemic responses to stress

Score: 13

DOI: 10.1038/s41586-025-09420-1

Similar Assertions

When you're stressed, a specific part of your brain sends a signal to your liver to make more sugar, and this happens because your body's 'fight or flight' system gets turned on.

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When mice get suddenly scared or stressed, a specific part of their brain sends a signal to their liver to quickly make more sugar, and this happens without needing their stress hormones or insulin/glucagon from the pancreas.

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When you're stressed, two types of brain cells in a specific area send signals to another part of the brain that tells your body to raise your blood sugar — even though one type excites and the other inhibits, both can make your blood sugar go up.

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