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Strong Support
quantitative
Analysis v1
History

Two specific genetic changes that can affect heart health are much more common in African Americans than in white Americans.

32
Pro
0
Against

Evidence from Studies

Supporting (1)

32

Community contributions welcome

32

Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9

Cross-Sectional Study
Human
2005 Feb

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

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Source Study

Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9

Score: 32
DOI: 10.1038/ng1509

Similar Assertions

Some people of African descent have genetic changes in a gene called PCSK9 that seem to cut bad cholesterol levels by almost half—this might help explain why they have lower heart disease risk.

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