AURKA, CCND1, and RAD51 are upregulated in ovarian cancer tissues and are potential molecular targets of aspartame, as identified through integrated network toxicology and machine learning analysis of multi-omics data.

Aspartame attaches to three specific proteins in ovarian cells, making them more stable and active. One protein forces cells to divide faster, another helps cells move past a checkpoint that normally stops abnormal growth, and the third repairs DNA damage that would otherwise kill the cells. Together, these changes let cancer cells multiply uncontrollably and survive despite damage.