Very high protein diets may harm very sick people with kidney injury by increasing toxins and risk of death.
Evidence from Studies
No evidence studies found yet.
What Would Prove This
Per GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this claim, ordered from strongest to weakest.
Causal effect of protein dose on outcomes in critical illness with AKI.
An RCT with 500+ mechanically ventilated AKI patients randomized to high (≥2.0 g/kg/day) vs. standard (1.0-1.3 g/kg/day) protein, measuring mortality, dialysis need, and urea levels as primary endpoints.
Real-world associations between protein intake and AKI outcomes.
A multicenter cohort study of 2,000+ ICU patients with AKI, tracking protein intake, urea levels, and clinical outcomes.
Pooled evidence on protein dosing in critical care with AKI.
A systematic review of RCTs and observational studies on protein intake in critically ill AKI patients, with meta-analysis of mortality and renal outcomes.