mechanistic
Analysis v1
Strong Support
A form of vitamin D can calm down immune cells when they overreact to bacteria by turning off a key inflammation signal, which helps produce a protein that puts the brakes on the immune response.
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Evidence from Studies
Supporting (1)
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Community contributions welcome
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1,25-Dihydroxyvitamin D Promotes Negative Feedback Regulation of TLR Signaling via Targeting MicroRNA-155–SOCS1 in Macrophages
Case-Control Study
Animal
2013 Apr 1Vitamin D helps calm down the immune system’s overreaction to bacteria by turning down a gene (miR-155) that blocks a natural brake (SOCS1) on inflammation. This lets the body stop the inflammation faster.
Contradicting (0)
0
Community contributions welcome
No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.