The Claim

In murine C2C12 skeletal myotubes, 1,25(OH)2-vitamin D3 enhances the activation of the Akt/mTOR signaling pathway in response to leucine and insulin, suggesting that it potentiates anabolic signaling in muscle cells.

Source: 1,25(OH)2-vitamin D3 enhances the stimulating effect of leucine and insulin on protein synthesis rate through Akt/PKB and mTOR mediated pathways in murine C2C12 skeletal myotubes.

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
9score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
1 study reviewed
In plain English

In muscle cells from mice, a form of vitamin D makes the cells respond stronger to leucine and insulin, which are signals that tell the body to build muscle — so it might help muscles grow better.

See the scientific wording

In murine C2C12 skeletal myotubes, 1,25(OH)2-vitamin D3 enhances activation of the Akt/mTOR signaling pathway in response to leucine and insulin, suggesting it potentiates anabolic signaling in muscle cells.

What the research says

1 study
  1. Study: 1,25(OH)2-vitamin D3 enhances the stimulating effect of leucine and insulin on protein synthesis rate through Akt/PKB and mTOR mediated pathways in murine C2C12 skeletal myotubes.

    The study found that adding vitamin D to muscle cells makes them respond stronger to leucine and insulin, which are signals that tell muscles to grow. This means vitamin D helps muscles build protein better.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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