The Claim
Vitamin D suppresses microRNA-155 transcription in macrophages by enabling vitamin D receptor signaling to block NF-κB binding to a specific DNA element in the first intron of the bic gene, thereby exerting an anti-inflammatory effect.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Vitamin D helps calm inflammation in certain immune cells by stopping a specific switch in the cell’s DNA from turning on a molecule that causes inflammation.
See the scientific wording
The anti-inflammatory effect of vitamin D in macrophages is mediated through a specific DNA element in the first intron of the bic gene, where vitamin D receptor signaling blocks NF-κB binding to suppress microRNA-155 transcription.
What the research says
1 studyVitamin D helps calm down inflammation in immune cells by blocking a specific DNA switch that would otherwise turn on a trouble-making molecule called miR-155. This switch is right inside a gene called bic, and vitamin D stops a protein (NF-κB) from activating it.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.