When untrained young men lift weights with different heavy loads but equal total work, their chest muscles grow about the same amount—around 10-11% bigger.
Evidence from Studies
Supporting (2)
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Effects of 4, 8, and 12 Repetition Maximum Resistance Training Protocols on Muscle Volume and Strength.
The study found that lifting weights with different rep ranges but the same total work led to similar muscle growth in the chest, just like the claim said.
Effects of 4, 8, and 12 Repetition Maximum Resistance Training Protocols on Muscle Volume and Strength.
The study did the same training as the claim says and found that all three types of workouts made chest muscles grow about the same amount, which matches what the claim says.
Contradicting (1)
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Effects of different intensities of resistance training with equated volume load on muscle strength and hypertrophy
The study used different weights (like 20% to 80% of max) and found that heavier weights grew muscles more than lighter ones, which goes against the idea that all weights work the same for muscle growth when volume is matched.
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.