mechanistic
Analysis v1
Strong Opposition
When you walk, the movement of blood through your blood vessels creates a gentle force called shear stress. This triggers your blood vessel walls to produce more of a molecule called nitric oxide, which widens your blood vessels and helps prevent blood clots that can lead to heart disease.
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Evidence from Studies
Supporting (0)
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Community contributions welcome
No supporting evidence found
Contradicting (1)
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Community contributions welcome
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Modulation of low shear stress-induced eNOS multi-site phosphorylation and nitric oxide production via protein kinase and ERK1/2 signaling
Cross-Sectional Study
In Vitro
2017 FebThe study tested low shear stress on blood vessel cells and found it actually REDUCES nitric oxide production (which helps prevent blood clots), contradicting the claim that walking-induced shear stress increases nitric oxide for protection against artery disease.
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