Consuming 2.34 grams of phytate daily with a liquid diet lowers the amount of zinc the body absorbs by nearly half, from 34% to 17.5%, when the ratio of phytate to zinc in the diet is 15:1.
Mechanism
Synthesis from 1 study
Phytate in food binds to zinc in the gut and turns it into a solid that can't be absorbed. This means the zinc just passes through the body and comes out in poop instead of entering the bloodstream, so less zinc gets used by the body.
Most probable mechanism
When phytate is eaten, it binds tightly to zinc in the gut, forming a solid clump that the body cannot absorb. This clump passes through the intestines and is pooped out instead of letting zinc enter the bloodstream, so less zinc gets into the body.
Phytate (inositol hexaphosphate) in the intestinal lumen binds to free zinc ions under physiological pH conditions, forming a stable, insoluble complex.
The phytate-zinc complex resists degradation by gastrointestinal enzymes and remains intact throughout the digestive tract.
The insoluble complex prevents zinc from accessing zinc transporters on the surface of intestinal cells, blocking its entry into the cells.
Reduced zinc uptake into intestinal cells leads to decreased zinc transport into the bloodstream and lower systemic zinc levels.
Unabsorbed zinc is excreted in feces, while urinary zinc excretion declines due to reduced systemic zinc availability.
Evidence from Studies
Supporting (1)
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A stable isotope study of zinc absorption in young men: effects of phytate and a-cellulose
Contradicting (0)
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