The Claim
In healthy human volunteers, co-administration of 20 mg piperine with 2 g curcumin increases curcumin bioavailability by 2000% compared to curcumin alone, as measured by the area under the serum concentration-time curve, due to inhibition of hepatic and intestinal glucuronidation, which significantly enhances systemic exposure to curcumin despite its otherwise negligible absorption.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
When 20 mg of piperine is taken with 2 g of curcumin in healthy humans, the amount of curcumin absorbed into the bloodstream increases by 2000% compared to taking curcumin alone, because piperine blocks enzymes in the liver and intestines that break down curcumin.
See the scientific wording
In healthy human volunteers, co-administration of 20 mg piperine with 2 g curcumin increases curcumin bioavailability by 2000% compared to curcumin alone, as measured by the area under the serum concentration-time curve, due to inhibition of hepatic and intestinal glucuronidation, which significantly enhances systemic exposure to curcumin despite its otherwise negligible absorption.
Piperine blocks enzymes in the intestine and liver that break down curcumin, allowing more curcumin to enter the bloodstream unchanged and stay in the body longer.
What the research says
1 studyStudy: Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers
When people took piperine (from black pepper) along with curcumin (from turmeric), their bodies absorbed 20 times more curcumin than when they took curcumin alone, because piperine stopped the body from breaking it down too fast.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.