When a certain type of human ovary cell is exposed to a specific amount of linoleic acid, it starts to die off more — and this might explain why high levels of this fat could mess with egg development.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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Linoleic acid induces human ovarian granulosa cell inflammation and apoptosis through the ER-FOXO1-ROS-NFκB pathway

Cross-Sectional Study

In Vitro

2024 Mar 16

The study shows that linoleic acid causes cell death in human ovarian granulosa cells, which supports the idea that high levels of this fat might harm these cells.

Contradicting (0)

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Source Study

Linoleic acid induces human ovarian granulosa cell inflammation and apoptosis through the ER-FOXO1-ROS-NFκB pathway

Score: 6

DOI: 10.1038/s41598-024-56970-x

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