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Back to Study: ERK1/2 Mediates Insulin Stimulation of Na,K-ATPase...
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Strong Support

When a certain protein in human muscle cells is blocked, insulin can't turn on or move a key cellular pump that helps muscles work properly.

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Pro
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Against

Evidence from Studies

Supporting (1)

3

Community contributions welcome

3

ERK1/2 Mediates Insulin Stimulation of Na,K-ATPase by Phosphorylation of the α-Subunit in Human Skeletal Muscle Cells*

Cross-Sectional Study
In Vitro
2004 Jun 11

The study tested exactly what the claim says: blocking a specific signal (MEK1/2) with a drug (PD98059) stopped insulin from activating a key cellular pump in human muscle cells. The results match the claim perfectly.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

ERK1/2 Mediates Insulin Stimulation of Na,K-ATPase by Phosphorylation of the α-Subunit in Human Skeletal Muscle Cells*

Score: 3
DOI: 10.1074/JBC.M402152200

Similar Assertions

Insulin helps move certain proteins to the surface of human muscle cells and boosts their activity, and this seems to involve a specific cellular signaling process.

3
0
80%

When insulin acts on human muscle cells, it turns on a switch (ERK1/2) that helps modify a specific protein (the sodium-potassium pump) at certain spots—this has been seen in lab tests using drugs and purified enzymes.

3
0
79%

When you eat, your body releases insulin, which helps muscle cells pull more potassium from your blood by putting more pumps on their surface—this keeps your muscles working smoothly after meals.

1
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73%

When rats are given insulin, a specific part of a pump in their muscle cells moves from inside the cell to the outer membrane, but another similar part stays where it is.

6
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73%

When insulin is present, certain parts of a pump in rat muscle cells move to the surface of the cell—these parts work together like a team that responds to insulin.

6
0
72%