The Claim

In differentiated primary human skeletal muscle cells, inhibition of MEK1/2 using PD98059 completely prevents insulin-induced activation, phosphorylation, and plasma membrane translocation of Na,K-ATPase alpha-subunits.

Source: ERK1/2 Mediates Insulin Stimulation of Na,K-ATPase by Phosphorylation of the α-Subunit in Human Skeletal Muscle Cells*

What the research says

Roughly balanced

Support and challenge are close. The picture may shift as more studies come in.

Supports
3score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
1 study reviewed
In plain English

When a certain protein in human muscle cells is blocked, insulin can't turn on or move a key cellular pump that helps muscles work properly.

See the scientific wording

Inhibition of MEK1/2 with PD98059 abolishes insulin-stimulated Na,K-ATPase activation, phosphorylation, and plasma membrane translocation of alpha-subunits in differentiated primary human skeletal muscle cells.

What the research says

1 study

  1. Study: ERK1/2 Mediates Insulin Stimulation of Na,K-ATPase by Phosphorylation of the α-Subunit in Human Skeletal Muscle Cells*

    The study tested exactly what the claim says: blocking a specific signal (MEK1/2) with a drug (PD98059) stopped insulin from activating a key cellular pump in human muscle cells. The results match the claim perfectly.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.