mechanistic
Analysis v1
Strong Support
When there’s too much of a protein called DAX-1 in mouse testicle cells, it blocks the thyroid hormone from doing its job—preventing the cells from making progesterone, a hormone needed for reproduction.
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Evidence from Studies
Supporting (1)
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Community contributions welcome
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Molecular Mechanisms of Thyroid Hormone-stimulated Steroidogenesis in Mouse Leydig Tumor Cells
Cohort Study
Animal
1999 Feb 26When scientists added extra DAX-1 protein to mouse testicle cells, it blocked the thyroid hormone from doing its job of making steroid hormones — proving DAX-1 acts like a brake on the hormone’s effect.
Contradicting (0)
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No contradicting evidence found
Gold Standard Evidence Needed
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