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Analysis v1

In a laboratory cell line derived from pituitary tissue, removing both versions of the thyroid hormone receptor prevents the hormone T3 from suppressing the production of Tshb mRNA, even when T3 is present at very high levels.

Evidence from Studies

Supporting (1)

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Fundamentally distinct roles of thyroid hormone receptor isoforms in a thyrotroph cell line are due to differential DNA binding.

Computational/Algorithm Study
In Vitro
2012 Jun

When both of the two special protein keys (THRA and THRB) that help control thyroid hormone signals are removed, the cell can’t respond to even a very strong dose of thyroid hormone. This means you need at least one of the keys to make the system work.

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No contradicting evidence found

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Source Study

Fundamentally distinct roles of thyroid hormone receptor isoforms in a thyrotroph cell line are due to differential DNA binding.

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DOI: 10.1210/me.2011-1290

Similar Assertions

In a laboratory cell line derived from pituitary tissue, removing the thyroid hormone receptor beta prevents T3 from suppressing the production of Tshb mRNA, while removing receptor alpha does not, indicating that receptor beta is required for T3 to reduce Tshb mRNA levels under physiological conditions.

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92%

When the THRB protein is removed from a specific type of pituitary cell in the lab, more THRA protein binds to the DNA region that controls the Tshb gene.

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88%

In certain pituitary tumors that overproduce TSH, the genetic instructions for thyroid hormone receptors are present and readable, but the receptors themselves are not made, suggesting a problem occurs after the genetic code is copied but before the protein is assembled.

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71%

In certain benign tumors of the pituitary gland that overproduce TSH, the lack of thyroid hormone receptors prevents thyroid hormone from signaling the tumor to stop releasing TSH, leading to elevated thyroid hormone levels alongside abnormally high TSH.

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71%