The Claim
In the TαT1.1 pituitary thyrotroph cell line, simultaneous depletion of thyroid hormone receptor isoforms THRA and THRB eliminates T3-mediated suppression of Tshb mRNA expression, even at a T3 concentration of 100 nM.
What the research says
Not yet evaluated
We are still looking at what the research says.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In a laboratory cell line derived from pituitary tissue, removing both versions of the thyroid hormone receptor prevents the hormone T3 from suppressing the production of Tshb mRNA, even when T3 is present at very high levels.
See the scientific wording
In a pituitary thyrotroph cell line (TαT1.1), simultaneous depletion of both thyroid hormone receptor isoforms (THRA and THRB) abolishes T3-mediated suppression of Tshb mRNA even at high concentrations (100 nM), suggesting that either receptor can mediate suppression under extreme hormone conditions.
What the research says
1 studyWhen both of the two special protein keys (THRA and THRB) that help control thyroid hormone signals are removed, the cell can’t respond to even a very strong dose of thyroid hormone. This means you need at least one of the keys to make the system work.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
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