The Claim
Elevated calcium concentrations of 10 mM induce a growth-phase-dependent activation of the glyoxylate shunt in Pseudomonas aeruginosa during stationary phase, resulting in increased levels of glyoxylate (3.47 LFC) and α-ketoglutarate (1.89 LFC), which reduces NADH production and conserves carbon.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In Pseudomonas aeruginosa bacteria during stationary phase, high calcium levels trigger a metabolic shift that increases glyoxylate and α-ketoglutarate, reduces NADH production, and conserves carbon.
See the scientific wording
Elevated calcium concentrations (10 mM) induce a growth-phase-dependent activation of the glyoxylate shunt in Pseudomonas aeruginosa during stationary phase, increasing key metabolites such as glyoxylate (3.47 LFC) and α-ketoglutarate (1.89 LFC), which may enhance bacterial survival under oxidative stress by conserving carbon and reducing NADH production.
When calcium levels rise, the bacteria switch their energy production to a shortcut that saves carbon and makes less NADH, which helps them survive attacks from reactive oxygen molecules in the lungs.
What the research says
1 studyStudy: Calcium regulation of Pseudomonas aeruginosa metabolism.
When there’s a lot of calcium, like in the lungs of cystic fibrosis patients, this bacteria changes how it makes energy to save resources and better survive the stress — and the study proved it makes more of the key energy-saving molecule glyoxylate.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.