When chicken muscle cells are starved, adding creatine seems to boost a key protein for energy and reduce harmful molecules, which might help the cells' powerhouses work better under stress.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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The regulating pathway of creatine on muscular protein metabolism depends on the energy state.

Cross-Sectional Study

Animal

2022 May 1

The study tested creatine in chick muscle cells when they were starved of nutrients, and found it boosted a key protein (PGC-1α) and reduced harmful molecules (ROS), just like the claim says.

Contradicting (0)

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

The regulating pathway of creatine on muscular protein metabolism depends on the energy state.

Score: 8

DOI: 10.1152/ajpcell.00447.2021

Similar Assertions

When chicken muscle cells are starved, adding creatine seems to lower levels of two proteins that make muscles waste away — this might mean creatine helps protect muscles when there's not enough energy.

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83%

In chicken muscle cells with normal energy, adding creatine seems to boost protein building and turn on key muscle growth switches in the cells.

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79%

Creatine helps protect tiny muscle cells from shrinking when they're starved, but only when there's no sugar around — it seems to work only when energy is low.

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78%