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Strong Support

In chicken muscle cells with normal energy, adding creatine seems to boost protein building and turn on key muscle growth switches in the cells.

8
Pro
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Against

Evidence from Studies

Supporting (1)

8

Community contributions welcome

8

The regulating pathway of creatine on muscular protein metabolism depends on the energy state.

Cross-Sectional Study
Animal
2022 May 1

The study gave creatine to chick muscle cells in normal conditions and found it boosted protein production and activated a key muscle growth pathway, just like the claim says.

Contradicting (0)

0

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

The regulating pathway of creatine on muscular protein metabolism depends on the energy state.

Score: 8
DOI: 10.1152/ajpcell.00447.2021

Similar Assertions

When chicken muscle cells are starved, adding creatine seems to lower levels of two proteins that make muscles waste away — this might mean creatine helps protect muscles when there's not enough energy.

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84%

When chicken muscle cells are starved, adding creatine seems to boost a key protein for energy and reduce harmful molecules, which might help the cells' powerhouses work better under stress.

8
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79%

Creatine helps protect tiny muscle cells from shrinking when they're starved, but only when there's no sugar around — it seems to work only when energy is low.

8
0
79%

Taking creatine supplements might help your muscles and brain store more energy, which could keep your cells from running out of power, help build muscle, stop muscle from breaking down, and keep your cell walls stable.

1
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71%

If you take creatine and get bigger muscles, it’s probably because you’re working out more, not because creatine is changing how your muscles build protein when you’re just sitting around.

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71%