The Claim
In human HAP1 cells, intracellular creatine concentration exhibits a direct and inverse correlation with AGAT protein expression, with half-maximal suppression (IC50) occurring at approximately 1–2 mM intracellular creatine, indicating a potential intracellular creatine-sensing mechanism that dynamically regulates creatine biosynthesis to maintain cellular homeostasis.
What the research says
Roughly balanced
Support and challenge are close. The picture may shift as more studies come in.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In certain human cells, the more creatine builds up inside, the less the cell makes on its own — like a built-in thermostat that senses creatine levels and turns down production when there's enough.
See the scientific wording
In human HAP1 cells, intracellular creatine concentration directly and inversely correlates with AGAT protein expression, with a half-maximal suppression (IC50) occurring at approximately 1–2 mM intracellular creatine, suggesting the presence of an intracellular creatine-sensing mechanism that dynamically regulates creatine biosynthesis to maintain cellular homeostasis.
What the research says
1 studyThe study shows that when creatine builds up inside human cells, the cell makes less of the AGAT protein, just like the claim says. This suggests cells can 'sense' how much creatine they have and adjust production accordingly.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
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