A genetically modified strain of E. coli, designed to produce a protein that neutralizes colibactin, significantly lowers the levels of a harmful E. coli strain in the intestines of mice.

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Evidence from Studies

Supporting (1)

40

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40

Surface expression of antitoxin on engineered bacteria neutralizes genotoxic colibactin in the gut

Randomized Controlled Trial

Human & Animal & In Vitro

2026 Jan

Scientists made harmless E. coli bacteria wear a special shield (ClbS) that neutralizes a toxic chemical made by harmful E. coli in the gut. This shield made the harmful bacteria weaker and less able to take over, which is exactly what the claim says.

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Surface expression of antitoxin on engineered bacteria neutralizes genotoxic colibactin in the gut

Score: 40

DOI: 10.1038/s41564-025-02177-3

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