Analysis Version
v1
History
Back to Study: 'That's the Esketamine, Baby, there's Nothing You ...
correlational
Analysis v1
20
Pro
0
Against

Giving esketamine through an IV can quickly and lastingly lift depression in adults who haven’t responded to other treatments.

Claim Language

Language Strength

association

Uses association language (linked to, correlated with)

The claim uses the phrase 'is associated with,' which indicates a statistical or observational link rather than a direct cause-and-effect relationship, placing it in the 'association' category.

Context Details

Domain

medicine

Population

human

Subject

Intravenous esketamine

Action

is associated with

Target

rapid-acting and sustained antidepressant effects in adults with treatment-resistant or refractory major depressive disorder

Intervention Details

Type: pharmacological

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Evidence from Studies

Supporting (1)

20
20

'That's the Esketamine, Baby, there's Nothing You Can Do about It!' An Update on Glutamatergic System in Suicidal Depression.

Systematic Review
Human
2020

The study found that when esketamine is given through an IV drip, it quickly and lastingly helps people with severe depression that didn’t respond to other treatments — which is exactly what the claim says.

Contradicting (0)

0
No contradicting evidence found

Source Study

'That's the Esketamine, Baby, there's Nothing You Can Do about It!' An Update on Glutamatergic System in Suicidal Depression.

Score: 20
DOI: 10.2174/1568026620666200131100316

Similar Assertions

When people with severe depression that hasn’t responded to regular antidepressants get a nasal spray called esketamine along with their usual meds, they tend to feel a little better after a few weeks—about as much as if they added a different type of psychiatric pill.

33
0
89%

For people with depression that hasn’t responded to other treatments, using a nasal spray called esketamine for six months may significantly help lift their mood, based on standard depression scores.

31
0
86%

For people with depression that hasn’t responded to other treatments, a nasal spray called esketamine helps a little bit — and it works about as well as adding another type of psychiatric medication.

33
0
84%

In two people with severe depression that didn’t respond to other treatments, a nasal spray called esketamine made them feel better at first, but then their mood got worse again—like a quick high followed by a crash.

20
0
83%

Some studies show that a nasal spray called esketamine helps with severe depression, but other bigger studies don’t show the same level of help—so scientists are confused about whether it really works as well as first thought.

20
0
83%