The Claim
In healthy adults undergoing 38 hours of total sleep deprivation, acute caffeine intake (2.5 mg/kg at 9:00 and 14:00) significantly increases systolic and diastolic blood pressure and elevates plasma interleukin-6 levels compared to placebo.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In healthy adults deprived of sleep for 38 hours, taking caffeine at two specific times increases blood pressure and raises levels of the inflammatory marker interleukin-6 compared to taking a placebo.
See the scientific wording
In healthy adults undergoing 38 hours of total sleep deprivation, acute caffeine intake (2.5 mg/kg at 9:00 and 14:00) significantly increases systolic and diastolic blood pressure and elevates plasma interleukin-6 levels compared to placebo, indicating a provocation of cardiovascular and inflammatory stress responses during sleep loss.
Caffeine blocks signals that normally calm blood vessels and reduce inflammation, causing blood vessels to tighten and blood pressure to rise. At the same time, it triggers immune cells to release more inflammatory molecules, which further stress the blood vessels and worsen the body's response to being awake for a long time.
What the research says
1 studyWhen people stay awake for almost 40 hours, drinking caffeine at midday and afternoon makes their blood pressure go up more and triggers more inflammation in their body than if they didn’t drink caffeine. The study proved this happens.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.