When healthy adult men at high altitude consume significantly fewer calories than they burn for three weeks, they lose about 3.6 kilograms of lean body mass, whether they eat 1.0 or 2.0 grams of protein per kilogram of body weight daily.

46

Pro

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Against

Evidence from Studies

Supporting (1)

46

Community contributions welcome

46

Severe negative energy balance during 21 d at high altitude decreases fat‐free mass regardless of dietary protein intake: a randomized controlled trial

Randomized Controlled Trial

Human

2018 Feb

Even if men ate twice as much protein while at high altitude and eating far fewer calories, they still lost the same amount of muscle — meaning more protein didn’t help protect their muscles in this extreme situation.

Contradicting (0)

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Severe negative energy balance during 21 d at high altitude decreases fat‐free mass regardless of dietary protein intake: a randomized controlled trial

Score: 46

DOI: 10.1096/fj.201700915R

Similar Assertions

When healthy adult men are in a state of severe calorie deficit at high altitude, consuming 2.0 grams of protein per kilogram of body weight per day leads to a higher rate of protein breakdown compared to consuming 1.0 gram per kilogram, resulting in a greater overall loss of body protein.

46

0

74%

When healthy adult males experience extreme calorie restriction at high altitudes, they lose about the same amount of body fat as they do muscle and other lean tissues.

46

0

74%

When young healthy men eat fewer calories than they burn, their bodies burn slightly more energy at rest than expected based on the muscle they lose, suggesting other biological changes are contributing to this effect.

46

0

71%